When it comes to shear, the intensity and direction can matter a lot. For most systems, light shear can be overcome, but moderate to high shear can keep an Invest from developing and hold even well developed systems in check.
Sometimes, the direction of shear can actually help the low ventilate and strengthen. A great recent example of this was Isaias, which muddled along in the western Atlantic and was first sheared by a with southwesterly shear until it started changing its direction to the NNE, which allowed for the shear to become a help rather than a hinderance.
Here, while there is definitely shear around, it looks like the wave is going to come off Africa at a low enough latitude where shear shouldn't be too much of an issue early on.
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I think the bigger issues early on may be mid-level dry air and some residual instability and fast forward motion, with shear an issue by the time it gets to the Antilles. Our orange needs convection and a nice moisture envelope to develop the way the GFS tries to predict.
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It's a messy image, but note the central Atlantic near the islands. There's an upper low that imparts some significant westerly/SW shear on the low and it really tears it up. This far out though, those kind of placements really are hard to predict accurately.