Lava Rock

what is the scientific explanation as to why cases increase with more mask use?

Apparently Maine is now the worst in the country for virus reproduction rate. Just exploding here.

Blew the doors off previous records. The CAR temp is usually their avg high in early july

DNA vaccines and in this case mRNA vaccines would likely be taken up by myocytes (muscle cells of the arm). While not the optimal antigen presenting cells (APC), they have the proper co-stimulatory molecules on their surface to present the vaccine antigens to T cells. More potent APCs would be interstitial dendritic cells and these would also be present, albeit to lower levels then muscle cells. Unless there is a secretion signal sequence encoded as part of the expressed spike protein for extracellular transport, the majority of the vaccine would be expressed intracellularly and loaded into Class I MHC for cellular CD8 T cell responses, but some vaccine antigen can and will be dumped extracellularly which would elicit the antibody response. There may be some microtissue trauma from needle injection which causes some minor inflammation, aiding in recruitment of immune cells. mRNA degrades pretty quickly even during "normal" bodily gene expression, but I think I recall hearing this vax is delivered in a liposome which provides enhanced protection against degradation.

yeah pfz manufactured and the govt prepaid for a bunch of doses months ago regardless if the trial failed. quite the gamble, but thankfully it appears to be a success

actually 660 million since the vax requires 2 doses.

gotcha

dry ice.

Other companies are also using similar/same technology as the PFZ vax, so they must be shady too? I do think the timing is just a wee bit suspect, but maybe just a coincidence. Either way, the news is the best thing we've had all year.

90% effectiveness is remarkable, especially when a lot of people were thinking flu-like effectiveness of 40-60%. If the data holds, this is the beginning of the end for covid, make no mistake about it. Sort out the logistics and let's put an end to this.

That's hilarious, but if it works why not

Time to start over

Oxbow, in oxford. They don't brew here though

Pizza and beer for lunch after short hike. Another buet day

Or down....

In Naples for dinner. Just friggin great eating outside still. 62F

Cape Elizabeth

Absolutely stunning weather. 72.6F. Great riding weather

Warm already. 62F

Not sure it's all garbage. Case number is rapidly rising, near exponential. If we start approaching 2000 deaths/day, it's off to the races I think.

Mills just did it here.

In one of my covid reddit feeds

Will there be delayed resort openings you think? With T-Day only 3 wks away, when's the next window to make snow?

That's the odd thing. I am on downside of the riding season, so have lost a little fitness, but my numbers right now should be the best they could be for this time of the year and yet they are the worst. Same thing happened last year at my physical. Tried a statin, but got sore legs within 6wks. Went to a much better (partial vegan) diet in Jan, wasn't drinking any IPAs mot of the winter and when I got my chol checked in May, it was the best it's been in over 10yrs. Even better than when I was taking the statin for a couple months. My PCP said diet wouldn't do much for my numbers, but I have proof it certainly can. My cardiologist didn't think I needed to be on a statin based on my results in addition to CRP levels (always <1) so I tend to put more faith in his recommendation than my PCP. I've requested a calcium score cause I really want to see where things are internally with respect to build-up. Like I said I eat way too many carbs. My breakfast rotates between oatmeal or eggs and piece of toast with PB. When I look at strictly my oatmeal mornings with added honey, whole grain bread with PB and half banana and half cup OJ, my carb intake is ~125g! That's stupid. All getting broken down to simple sugars and massive blood glucose rise no doubt. No wonder my #'s are up including my triglycerides and even BP. And that's just breakfast. Lunch tends to be more protein based (chix), but two more pieces of bread, crackers and a granola Kind bar (more carbs/sugar). My wife tells me not to eat so much oatmeal, but I feel like 1cup is enough to keep my filled for most of morning, but one cup has 60g carbs. Dietary recommendations based on 2000 cal/day diet says to get ~200-300g carbs, which is probably where I land by dinner time, but that just seems like too much.

I monitor my cholesterol once or twice a year and as much as I love IPA's, I think they are partially responsible for my recent (and other times) high levels. I eat way too many carbs (my fault, but somewhat necessary for cycling season), but the beers don't help. I was reading on avg, craft beers have ~1.5g residual sugar per ounce with for one pint equates to 24g sugar. I'll throw down 2-3 pints on avg every night between Fri-Sun nights during the summer and early Fall. Aside from all the carbs, that's a crap ton of extra sugar. I switch to wine during the Winter which is better for carbs (lower), but still has residual sugar depending on sweetness. I told my wife we should cut back on alcohol. We'll routinely drink 0.5 - 0.75 of a bottle EACH on most Fri-Sun nights, so that's 1.5 bottles each over three nights. The boxed wines are evil as it's so easy to just doll out another glass not realizing how much you are drinking.