Initial reports are now saying that the vaccines have reduced efficacy on Covid strains which have the E484K (EEK)protein spike mutation. Apparently that mutation has reduced antibody binding properties and a decreased neutralizing antibody response triggered by the current mRNA vaccines. It is present in the B.1.351 variant (South Africa) and the P.1variant (Brazil). We are probably moving towards Covid becoming endemic but human adaptability is pretty remarkable so I for one am not going to get too rattled about it. The new variants will eventually become dominant (Brazil is on fire with P.1) and I doubt Americans will tolerate another round of lock downs, regardless of reduced effectiveness of vaccines against emerging strains. America seems done with the pandemic even if it is not done with us.