Lava Rock

70F on the way home. Nuts

And she'd be cool with that as we put that out there as an option, but she's 100% certain in her mind that she doesn't and won't have covid so no need to get tested. Of course she's back at work this week flying around the country then heading to LAX to see her brother and sister next week. All the more reason to at least get tested. I have to be careful how I say things. Marriages sure can be challenging.

Wife wants to go to a friend's house for dinner. They are older (70s) and have a 30yr son at home. I told her unless we get tested, I really don't want to go. Not because I think they may give it to us, but we to them. I just don't think it's worth it to sit and have dinner with people in a tight house. My mom and sister told us not to come, not that we usually celebrate together anyways, but my wife gets pissy when I tell her we probably should stay home. Both her parents have passed on now and we'd usually be in LAX for the holidays, but not anymore. I think she just feels this need to have to be with people during the holidays. Wonder how many other spousal relationships are having a bit of tough time with decisions like this.

Must have some house renovations coming up

I think our Gov is biting at the bit for lockdowns.

what is the scientific explanation as to why cases increase with more mask use?

Apparently Maine is now the worst in the country for virus reproduction rate. Just exploding here.

Blew the doors off previous records. The CAR temp is usually their avg high in early july

DNA vaccines and in this case mRNA vaccines would likely be taken up by myocytes (muscle cells of the arm). While not the optimal antigen presenting cells (APC), they have the proper co-stimulatory molecules on their surface to present the vaccine antigens to T cells. More potent APCs would be interstitial dendritic cells and these would also be present, albeit to lower levels then muscle cells. Unless there is a secretion signal sequence encoded as part of the expressed spike protein for extracellular transport, the majority of the vaccine would be expressed intracellularly and loaded into Class I MHC for cellular CD8 T cell responses, but some vaccine antigen can and will be dumped extracellularly which would elicit the antibody response. There may be some microtissue trauma from needle injection which causes some minor inflammation, aiding in recruitment of immune cells. mRNA degrades pretty quickly even during "normal" bodily gene expression, but I think I recall hearing this vax is delivered in a liposome which provides enhanced protection against degradation.

yeah pfz manufactured and the govt prepaid for a bunch of doses months ago regardless if the trial failed. quite the gamble, but thankfully it appears to be a success

actually 660 million since the vax requires 2 doses.

gotcha

dry ice.

Other companies are also using similar/same technology as the PFZ vax, so they must be shady too? I do think the timing is just a wee bit suspect, but maybe just a coincidence. Either way, the news is the best thing we've had all year.

90% effectiveness is remarkable, especially when a lot of people were thinking flu-like effectiveness of 40-60%. If the data holds, this is the beginning of the end for covid, make no mistake about it. Sort out the logistics and let's put an end to this.

That's hilarious, but if it works why not

Time to start over

Oxbow, in oxford. They don't brew here though

Pizza and beer for lunch after short hike. Another buet day

Or down....

In Naples for dinner. Just friggin great eating outside still. 62F

Cape Elizabeth

Absolutely stunning weather. 72.6F. Great riding weather

Warm already. 62F

Not sure it's all garbage. Case number is rapidly rising, near exponential. If we start approaching 2000 deaths/day, it's off to the races I think.