Wouldn't throw in the towel yet, even for the Ohio Valley.
For one, this storm is still several days out (so plenty of time for more shifts). Also, a fair number of the ensembles still have a track across the eastern lakes. But in addition, we know the models have had the tendency to be way too cavalier with how far west and how strong these systems get at this time frame. This storm could of course break that trend given the upper level features at play, but it's still something to keep in mind until we're closer in.