The only issue i have had with tomatoes is having way too many! lol last year I had one Tiny Tim tomato plant that ended up taking up an entire corner of my 10x10 bed.
But, as EJ mentioned, I have dealt with blossom rot (my squash, cucumbers and zucchini was hit hard by this last year). Last year when it happened we added crushed up Tums to the base of each plant to give some extra calcium and they bounced back.
My veggie garden doubles as our brush pile in the off-season, so this year after we burned our brush, we tilled in crushed up tums with the ash/charcoal from burnt brush. then I lay garden fabric down and that's it. we have chicken wire that goes around to keep the animals out, as the garden is set away from the house.
hopefully we don't have any blossom rot this year. fingers crossed. and the garden drains well so we never have standing water in it.