mattb65

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About mattb65

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    Kailua, HI

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  1. My arm where I got the shot was pretty sore especially when I used it so I'm pretty sure you're not going to want to do any heavy exertion until it gets better. Took about 48 hrs for me after each shot.
  2. As others noted, there are a number of problems here. 1. You can't add these two groups because there's a lot of overlap. 2. Vaccines give ~80-90% protection on average and infection probably also gives ~80% protection. So even if we somehow miraculously have no overlap, we're still at best around 75% population immunity which would definitely be sufficient. 3. Local level of immunity will be important, if the entire northeast is sitting at 70% of the population vaccinated + 10% with immunity through infection but not vaccinated then 80% total x 80% efficacy = 64% immune to virus introduced in that area, the virus will have a hard time finding new targets to sustain an outbreak. If you have the large sector of the southeast where only 50% get vaccinated + 15% immune through infection but not vaccinated then you get 65% total x 80% efficacy = 52% immune to virus introduction. Outbreaks still significantly mitigated but 12% would be a substantial difference. Fortunately it does seem like the elderly and high risk are getting the vaccine more so it may not matter in terms of the important metrics like death and disability. I'm still optimistic that things are overall going to be fine, everyone who doesn't want to get vaccinated will deal with the consequences ultimately. We're at the point where it is about choice and not access.
  3. As time goes on the total % vaccinated is becoming more and more similar to the 2020 election map, pretty remarkable, the consequences to the areas that have bought into the lies about the vaccines will probably be seen next fall and winter. I wonder if we see the per capita new infections and deaths start to look the same.
  4. This is an interesting study on how well natural infection induced immunity protects against reinfection. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00158-2/fulltext It was prospective and looked at usmc recruits. 10% of those with antibodies got infected and roughly 50% of those without antibodies got infected over a 6 week period. Based on this study, evidence of prior infection provided about an 80% protection. The reinfected individuals also had a lower viral load so probably less severe illness compared to the control group. Higher antibody levels also provided more protection. The study population was mostly young males so it may not necessarily apply to other ages/genders. Still interesting. Though not directly tested in the study, I think it implies that the mrna vaccine provide more protection against infection than natural immunity from prior infection.
  5. In this study there is exposure of lung cells in a petri dish to the spike protein. With the mrna vaccine, expression of the spike protein is induced in cells in the arm, and in the virus vector vaccines, the spike protein is also only in the muscle in the arm. The immune response then kicks in based on these foreign proteins in the arm. The theory from this paper is that the spike protein itself, not the immune response to the spike protein may contribute to the long term symptoms by affecting gene expression in cells exposed to purified spike protein. The vaccine doesn't expose lung cells to the spike protein, thus infection would cause these problems because lots of lung cells are exposed to the spike protein but not vaccination. This is all very theoretical though, there is not translational research to say whether or not the changes seen in this in vitro study would have the effects in vivo.
  6. Things are still on track for a good summer. The decline in first doses of the vaccine has been a bit steeper than expected but the decline in cases has also been a bit earlier and steeper than expected.
  7. https://www.bbc.com/news/world-asia-india-56891016
  8. Exactly, what's the point in him posting those pictures? Is it to prove that the NY Post is a garbage news source and a glorified tabloid? You don't need to convince me... Is it to downplay the covid situation in India? Seems like everything in India regarding covid is as bad as one could imagine right now. https://www.statnews.com/2021/04/27/in-covid-grip-india-gasps-for-air-if-there-is-an-apocalypse-this-has-to-be-one/
  9. @Hoosier West Virginia is getting creative at trying to improve their vaccination numbers West Virginia Gov. Justice: State will use COVID-19 stimulus funds to give all residents 16-35 a $100 savings bond https://www.wvnews.com/news/wvnews/west-virginia-gov-justice-state-will-use-covid-19-stimulus-funds-to-give-all-residents/article_3464b366-a6af-11eb-8cef-a3be246c97ac.amp.html
  10. This is hard to measure, if you look at covidactnow.org you can sort by daily cases per 100k or current infection Rt. Louisiana and Alabama have among the top 5 Rt but their current daily cases per 100k is in the bottom 10 in states. Hard to declare winners and losers I don't think there's been enough time to show a negative correlation between vaccination rates and infection rates between different states. Maybe check back in 6 months to see if there's been a difference between cases per capita and deaths per capita between high vaccine and low vaccine states.
  11. A private school in Miami, citing false claims, bars vaccinated teachers from contact with students. https://www.nytimes.com/2021/04/26/us/florida-centner-academy-vaccine.html
  12. I thought this was a good and balanced take on the transition from the first phase of vaccination where there was a pent up demand and a supply scarcity to the current phase where supply had caught up and it's about outreach to those on the fence and those that aren't highly motivated. Efforts should be on making it as painless as possible to get vaccinated, public education about the facts with transparency about the risks and benefits, and reasonable incentives for example Hawaii is launching its vaccine exemption to avoid quarantine for interisland travel and hopefully will do the same for transpacific travel not to long afterwards. It sounds like the CDC is going to be providing more and more guidance that being vaccinated makes a lot more fun things safe. I'm still very optimistic about the way ahead, of course it would have been nice to keep the numbers averaging over 3 million per day vaccinated for a little longer but we knew that wasn't going to happen based on the large chunk of people that have decided against vaccines for their variety of reasons. I think most of their reasons are misguided but it's their life and their free will, as a provider I'll be happy to discuss this with my patients and provide facts to help then make their own decision.
  13. This is a really good article that goes into the data on the blood clots from this vaccine and explains the rationale that different members of the advisory committee used in making their decisions. They also discuss the risks and benefits of different courses of action. https://www.cnn.com/2021/04/23/health/johnson-vaccine-acip-recommendation/index.html They present a lot of numbers in the risks/benefits section. "For every million doses of vaccine given to women 18 to 49, 13 TTS cases can be expected, Oliver said. But 12 deaths from Covid-19 would be prevented and 127 ICU admissions would be prevented among those women if they had access to the Janssen vaccine."
  14. This is definitely interesting, if the rough math I did before is still close to accurate this would correlate to a roughly 1 in 100,000 risk of this serious adverse reaction in women under 50. I wonder if there are other commonalities besides gender like being on combined oral contraceptives as an additional risk factor. I agree either a warning or even an outright restriction on giving it to women under 50 would both be reasonable. Even though the risk is small, the consequences are devastating. If I were in the at risk demographic I would 100% choose Pfizer or Moderna.