WhitinsvilleWX

LOL. He's ok. Just a typical engineer. I've known a bunch and they all have the same personality.

It's still 90%+. For comparison, the mumps vaccine is 78%. Highly successful vaccine BTW. Not as much breakthrough since less mumps circulate. Once covid circulation drops more, you'll see fewer breakthroughs.

Link? You may be a great engineer, but you know shit about pharma, clinical trials an drug development:

You do realize that when these are fully approved that there will be very little, if any, difference in data once they get the official stamp? I've told you before full vaccine trials that result in fully approved entities generally run 20,000 to 80,000 people. These trials ran the standard number of people and the safety data is obtained during the dose escalation during phase 1 What you posted is boiler plate insert wording because its required by federal law under an EAU designation. . Pembromizulab (Keytruda) is a first in class drug approved for lung cancer and melanoma. Its the first drug to block PD-1 and inhibit T-cell exhaustion. So just because these vaccines are mRNA vaccines doesn't mean they are any less appropriate. A lot of drugs get approved all the time that have a 1st in class MOA.

Who is calling? Sorry, you have the wrong number. Click

Same here. Ridiculous

My step mother had it. But it wasn’t AZ. Her’s was vascular. Thankfully that version takes you faster than AZ. With AZ you can linger for a long time.

I'll add: Part of the reason the FDA approved it is they were lobbied HARD! Not by Biogen, but buy AZ advocacy groups. I'll play both sides of the coin. On one hand, is it ethical to withhold a treatment for such a huge unmet medical need even if the data is sketchy. On the other hand, is it ethical to approve a drug that may not even work well (or even at all) and have government and private payers pay millions for reimbursement. Hard decision. But if I were the all powerful OZ, I wouldn't have approved it. Sets a bad precedent and somewhat reduces the efficacy requirements to that of snake oil.

That too. There's also vascular dementia. What used to be called "hardening of the arteries". Nothing much to be done there either. Everyone wants a fix to all the ills. Some things just cant be fixed but humans want them to be. Medical science can only do so much.

Its not a great drug. The trial results were iffy at best. The problem is that there's nothing out there to treat it. There's a class of drugs called acetylcholinesterase inhibitors (Aricept patch), and a class called NMDA receptor antagonists (Namenda). Both of these are short term fixes that don't get to the root of the plaque problem. In the end its a way to stave off the inevitable. The problem is that the biology of Alzheimer’s is poorly understood. In order to find a good treatment, the biology needs to be worked out better. I don't blame Biogen per se. They're a good well run company. People are desperate for a treatment. The FDA will watch it pretty close. If it's shown there's not a benefit, they will pull it down the road. They haven't done that very often but I think there's a shift in the thinking. If they approve a drug that could be beneficial for these "unmet needs" but based on sketchy data, the path going forward will be to pull it if there's no benefit after its been on the market.. Pricings a tough one. A lot goes into it. One of the reasons drugs cost a lot in the US is because they are mandated to be cheap in other countries. There needs to be more balance. And as I've said before, what institutions charge pharma companies to run clinical trials is criminal. Patent law needs to change to. Starting a patent run time when the structure is published is wrong. The patent duration needs to run longer once its on the market. There wouldn't be the need to recoup investment in such a short timespan. There's no easy answer.

Eh 3 minutes left. I doubt it Theyll have to win 2 in a row now. Tough road.

Tough night all around. Rask is having a horrible game too.

Bruins are sucking wind.

MLB knows and they dont really care. They may tsk tsk, but that’s perfunctory. They’ll never write in into the file book.

They have. Sami Sosa, McGuire, Clemens, etc etc on roids. Gaylord perry threw a spit ball. Joe Niekro got caught with a nail file. A lot of pitchers sharpened the metal snap on their pants to cut the ball. Clay Buckholtz used bullfrog sunscreen on his cap bill. Whitey Ford used mud and pine tar.

Yea, I'm tore up

That's the dirty secret of biological research. The NIH plays favorites. Why do you think old Ashish Jha is in the Globe and on CNN/MSNBC every other day? He's set himself up for life. He can send any POS grant application down to the NIH now and the study section will fund him because "He's Ashish Jha"!

Had to park a few blocks, but was t bad. It’s all $15. They’re building more parking closer. Foods not bad. Better than average. The have BT BBQ and George’s Coney Island. Although the dogs are a buck more than at George’s. The pizza is actually pretty good.

Sitting at the Woosox game. Really nice park. You central mass folks, I’d highly recommend going. Tickets are reasonable, the seats are wide, and the beer and concessions are easy in and out. And just for Fuji, 95% unmasked. But a lady in front of me has a mask and rubber gloves on. I’m sure she can wring water out of them at this point.

I’m sure I’ll get a weenie tag from the usual suspects. The Lancet and The New England Journal of medicine are edited by woke leftists with an agenda.

Nobody says you have to read it. Glad we could trigger you

My wife said she saw someone double masked at stop and shop yesterday.

I think some people need to see others without one before they’ll do it themselves. I’m happy to accommodate that.