WhitinsvilleWX

12 minutes ago, HoarfrostHubb said:

 

Amy good dining plans besides Brown Derby?  

Wife handle all that!

I know we’re doing LaCellier, Mexico, Morraco, and Norway at Epcot. I think one night we’re at California grill at the Contemporary.  
The problem with this trip is that there is no park hopper. You’re stuck eating dinner at the park you have reservations for on a particular  day. The original plan this trip was to do dinner at Epcot most nights, but without a park hopper that’s impossible. The Beach club is right there at the back entrance so it was easy to do. 
 

We wanted to do Tusker House but they’re  closed still so Yak and Yetti it is.

30 minutes ago, HoarfrostHubb said:

Do you use the Lines app?  The guy that runs that (Len Testa) is awesome

No. I just use the Disney app. I know it’s put out by Disney and could be rigged, but I’ve found when I’m down there in an actual line it’s pretty accurate.

One day we’re doing a private tour. All 4 parks, 8 hours. They take you in the rides the back way and you get right on. No waiting. 
You can basically do the biggies at each park in the 8 hours. They move you from park to park in a private van. Should be pretty cool. It better be for the price. 

1 minute ago, NorEastermass128 said:

I know you’re just trolling, but yes, towards the end of 21, early 22. Mask mandates will begin to ease. 

That’s about right. Vaccine or no vaccine, respiratory virus epidemics generally last about 18-20 months. 
Swine flu lasted about that long. 60 million Americans were infected but nobody cared because the death rate was low. Older people didn’t get it because they had some immunity from previous virus’ that were similar. 
 

2 minutes ago, forkyfork said:

at least we'll get a national mask mandate in january

Yea right. The feds can’t tell the states what to do. Did you skip civics?

But the feds could always blackmail them by threatening to withhold funding. Like that always do when the pesky 10th amendment gets in the way 

5 minutes ago, Chrisrotary12 said:

Was talking to my primary care's nurse during my last checkup and she mentioned how the long term effects were going to be interesting. Mentioned women were losing their hair specifically.

My wife had it back in December, we think. Couple months later the hair loss was outrageous. Not so you could tell it, but I had to clean the shower drain more than once.

9 minutes ago, CoastalWx said:

Is House going to Disney World? Heard the waits are terrible there. 

Lol

yes. Week from today

waits aren’t bad.  Thanksgiving is slow anyway. There’s an app that gives you wait time and nothing’s over 30 minutes generally. 
But the hotels at t giving any discounts let me tell you. Beach club villas are as outrageous ever. 

6 minutes ago, forkyfork said:

you guys keep making that number bigger and bigger. lol

ok, 99.5, 99.2, 99.0?  Pick what you want.

48 minutes ago, PowderBeard said:

A lot of ignorance and "it will never happen to me/my loved ones" in this thread. I'll leave it at that.

I don't think anyone said that.

I just don't choose to live my life locked up and scared over something that's 99.9% survivable. 

My kids are full time school. Private catholic.

I'm at work 5 days a week. My 78 yo father just got back from a 10 day trip in his RV

10 day trip to Disney World with the fam next week. Can't wait.

Life goes on

5 minutes ago, Baroclinic Zone said:

 vested interest

Semantics

14 minutes ago, Baroclinic Zone said:

Stock Market is a joke.  Little more then 1/2 of Americans have a vested interest in it.

https://www.forbes.com/sites/teresaghilarducci/2020/08/31/most-americans-dont-have-a-real-stake-in-the-stock-market/?sh=5764560e1154

Count me as one of them.  My employer bailed on 401K in 2008 crash.

This isn't true. Everyone has an interest either directly or indirectly. 

11 minutes ago, Lava Rock said:

DNA vaccines and in this case mRNA vaccines would likely be taken up by myocytes (muscle cells of the arm). While not the optimal antigen  presenting cells (APC), they have the proper co-stimulatory molecules on their surface to present the vaccine antigens to T cells. More potent APCs would be interstitial dendritic cells and these would also be present, albeit to lower levels then muscle cells. Unless there is a secretion signal sequence encoded as part of the expressed spike protein for extracellular transport, the majority of the vaccine would be expressed intracellularly and loaded into Class I MHC for cellular CD8 T cell responses, but some vaccine antigen can and will be dumped extracellularly which would elicit the antibody response. There may be some microtissue trauma from needle injection which causes some minor inflammation, aiding in recruitment of immune cells. 

mRNA degrades pretty quickly even during "normal" bodily gene expression, but I think I recall hearing this vax is delivered in a liposome which provides enhanced protection against degradation.

I figured it would be presented by MHC rather than dumped, mostly. Dendritic cells would be a good candidate. Never thought of the myocyte as a good APC. Not sure about that one. But is is one of the first cell types the mRNA would encounter. It is a liposome prep so degradation would be slowed, you're right about that. 

Lots of unknowns. mRNA vaccine research has been around a long time. I thought there would be more MOA known by now.

9 minutes ago, CoastalWx said:

I didn't think so, but he has a pic of Boston so I was wondering..lol. 

Derek Lowe, PhD is a medicinal chemist who writes a science blog call "In the Pipeline". He used to work at Vertex, but I think he changed jobs recently. He's still in Boston. Smart guy. He's written the blog for years.

1 hour ago, STILL N OF PIKE said:

 

The NEW Messenger RNA technology does have me personally concerned about LT side effects given a completely different mechanism for action that has never been approved.  

This technology thou was always going to get the M RNA delivery system over the line first. 

A protein subunit delivery system vaccine  has arguably been the favorite by many experts when it comes to guessing which delivery system will have best shot so we shall see how much this data turns that on its head.

The reason the mRNA method is so attractive is because large amounts can be manufactured more quickly than a traditional protein based antigen approach. 

The mRNA vaccine has a lot of questions about the mechanism. Not really the mechanism that produces the antigen (spike protein) per se, but the cell types that take up the mRNA to begin with. What cell types take up the RNA? How long do those cells crank out antigen? How long does it take for that mRNA to degrade? Does the host cell die after a time? Is the antigen released from the cell or does the cell present the antigen as non self though MCH class II mechanisms?

I've tried to get answers for these questions, but to no avail. I know people at pfizer, and I've asked them directly. Either they wont say because of proprietary reasons, or they don't know. My feeling is a lot of the latter. Not knowing the answers to the above questions wouldn't necessarily make it unsafe. Safety data doesn't really hinge on knowing exact mechanisms sometimes, but it would be nice to know. 

As a healthy adult with zero underlying conditions, and the fact I've been out from under the bed for 6 months at work, in restaurants, on public transport, etc, I'll take my chances with the Rona for awhile longer until more people get dosed up with it and see if they grow extra limbs.

Lava Rock may know a little more since vaccines are more up his alley than mine. I'm an immunologist and pathologist, but I make cancer drugs, not vaccines.

21 minutes ago, powderfreak said:

Bagging leaves is up there on top 5 worst chores you can possibly do.  Blow or rake into the woods all day long.

What’s this blowing, raking and bagging??

My Brazilian landscapers do a great job. I go to work one morning and when I get home my leaves are raked, perennials are cut, beds are raked shrubs are trimmed, grass gets a last mow and string trim, and I have a bourbon.

17 minutes ago, WhitinsvilleWX said:

I’m not very sensitive to pain meds either.  
I was in the ER for a kidney stone back in April and they gave me 2 doses of fentenyl and it didn’t do much. 

Toradol fixed me up.

I was on a gurney in the hallway at St V’s in Worcester. Height of the spring surge and all the ER rooms were reserved for virus patients. Only 2 in the whole ER when I was there, but I spent 6 hours parked in the hallway back there. I was a puddle just either hoping I’d pass away or pass out. The pain was unbearable. They asked me to rate it on a 1-10 scale. I said about 100.

7 minutes ago, HIPPYVALLEY said:

Yikes, 20 mg and I would be on the living room floor with the headphones and a Grateful Dead CD.  I’ve always been pretty sensitive to cannabis though. 
 

I’m not very sensitive to pain meds either.  
I was in the ER for a kidney stone back in April and they gave me 2 doses of fentenyl and it didn’t do much. 

16 hours ago, RUNNAWAYICEBERG said:

Enjoy it. It’s a glorious day. 5mg is perfect. 

5 mg doesn’t do squat for me. Like eating an M&M.

20 mg might get it if I dont eat much. I must not have enough of the enzyme that converts it. 
I use the tincture or do it the old fashion way. 

1 hour ago, PhineasC said:

Seems perfectly normal:

https://mkecitywire.com/stories/564495243-analysis-seven-milwaukee-wards-report-more-2020-presidential-votes-than-registered-voters-biden-nets-146k-votes-in-city

Analysis: Seven Milwaukee wards report more 2020 presidential votes than registered voters; Biden nets 146K votes in city

This kind of stuff happens all the time in every election I'm sure. It's just magnified in a close one.

Still baffles me we sent a men to the moon with the equivalent of a wire wrapped 4 k Commodore computer over 50 years ago and we cant keep track of voters and tally an election in 2020. 

21 minutes ago, powderfreak said:

Yup.  And most of the COVID stuff was Trump not keeping his mouth shut on some of the sound bites.  I honestly think if he just talked less, tweeted less, and didn't seem so contentious about everything he wins in a landslide.

It's not about Biden, this whole election is about Trump.  They could've ran an Alpaca up there for the Dems and it likely would've gotten the similar vote.  

^^^ THIS

1 minute ago, HoarfrostHubb said:

Nice! Get the Cobb Salad and Grapefruit Cake, as well as the Martini flight.  My brother went with his family in August.  He felt very safe, but make sure you obey the rules on property.  Also, no entertainment no fireworks, no real parades.  A much different experience.

 

I know someone who went last month. Crowds are low. Wait times are generally less than 30 minutes for most stuff. They suspended the fast pass but its really not needed right now.

Only thing that really stinks is there is no dining plan. We usually get the deluxe plan with the 3 sit downs. The way we eat with the 3 sit downs the dining plan is a good deal. They refunded us the money, but we'll probably end up paying a bit more for meals than what the dining plan refund was.

We're staying at the beach Club Villa's

. 

1 hour ago, CoastalWx said:

I’m just trying to get ideas and see what people are doing for the holidays. It really sucks. If there is one word that sums up the year for me, it’s frustration. 

Call me crazy, and I'm sure some will, but we're going to Disney World for 10 days over Thanksgiving. 

Planned the trip for over a year. We're still going. But we're not afraid of anything, so it really makes us no difference virus or no virus. 

Thanksgiving dinner at the Brown Derby in Hollywood Studios.

Nice little snow squall this morning. Not much, but it whitened up the mulch beds.

27 minutes ago, BrianW said:

 

Since Friday, there has been a net increase of 19 hospitalizations, bringing the state total to 129.

 

1.5% of beds in Connecticut with covid cases. ~8900 total beds in the state.

On 9/26/2020 at 1:26 AM, natedizel said:

What we need is some sort of better rapid swab test. Results in minute or something. All bars and concerts could open up and go on. You positive you cant enter. It would be like a bag check/metal detector line.

I don't post anymore on this stuff since the MPM thread was shut down. I figured what was the point.

But, a rapid antigen test that's specific would be what we need to end this mess.

I started looking into the PCR test a little more back in June. I was appalled to find out positives were being called at cycle number <40 (or <37 depending on the lab). I've used real time RT-PCR (or Taqman PCR) since 1997. We always discounted mRNA levels if the Ct value popped above 34-35. Not enough mRNA to make protein at any significant level. Several studies have been done that correlate Ct value with actual viral transfection assays, which is the gold standard. Ct values above 33-34 show no infectious viral particles are present. Yet the cut off still remains absurdly high. 

I'd love to see the Ct values that come back from these so called cluster events like on a swim team or frat house party. Chances are one kid actually had the sniffles for covid and the rest popped "positive" because they picked up some free mRNA or a few virus particles that their innate immune system took care of. You could find the same amount of mRNA in the entire household from flu A if someone in your house was positive by an antigen test for flu. They don't test for flu with PCR, and they shouldn't with this. Its too sensitive. The test itself is fine, but the interpretation needs to be adjusted to what's called positive.

I'm still not sure why no one has come out with a good rapid test. It takes 9-12 months to make a good, specific monoclonal antibody that's suitable for a rapid test, so hopefully that's not too far off. If they keep using PCR and calling "positives" at Ct values of <40, some places will stay locked down for ever since small amounts of mRNA will hang around for months.